AQA A Level Chemistry复习笔记7.7.4 DNA

• The nucleic acid DNA is a polynucleotide – it is made up of many nucleotides bonded together in a long chain
• A nucleotide is a building block consisting of a phosphate group, 2-deoxyribose and a nitrogenous base such as adenine, guanine, cytosine and thymine

The components that make up nucleotide in DNA

A DNA nucleotide

A single DNA polynucleotide strand showing the positioning of the ester bonds

Hydrogen bonding

• The two antiparallel DNA polynucleotide strands that make up the DNA molecule are held together by hydrogen bonds between the nitrogenous bases
• These hydrogen bonds always occur between the same pairs of bases:
  • The purine adenine (A) always pairs with the pyrimidine thymine (T) – two hydrogen bonds are formed between these bases
  • The purine guanine (G) always pairs with the pyrimidine cytosine (C) – three hydrogen bonds are formed between these bases
  • This is known as complementary base pairing
  • These pairs are known as DNA base pairs

   

A section of DNA – two antiparallel DNA polynucleotide strands held together by hydrogen bonds

Double helix

• DNA is not two-dimensional as seen in the diagram above
• DNA is described as a double helix
• This refers to the three-dimensional shape that DNA molecules form

DNA molecules form a three-dimensional structure known as a DNA double helix

• The weaker hydrogen bonds between the base pairs are more easily broken than the covalent bonds in the sugar-phosphate strands
• This is what allows the strands to break apart during cell division
• New nucleotides from the cells move in to pair up with the exposed bases, which then link by sugar-phosphate bonding and the helix molecules are replicated